ceesdekker No Further a Mystery
ceesdekker No Further a Mystery
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Midway by means of his vocation, Cees Dekker reinvented himself. Right after decades of hardcore physics, he shifted his emphasis to ‘nanobiology’ at the switch of the millennium. A phrase he coined himself, to be a issue of point.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
Multicolor imaging on the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
Non-equilibrium folding of specific DNA molecules recaptured as many as one thousand periods in a very stable condition nanopore
That is a aspiration of mine and we established to operate using a delectable dose of naivety. This can be a thing that will probably produce impressive results in the extended term, but that does not subject. You shouldn't only want to work on the inquiries of tomorrow, but in addition over the concerns on the working day after tomorrow.’
Our investigation ranges through the biophysics of DNA to artificial cells and over and above. Remember to take a look down below for the spectrum of our latest jobs.
‘In the beginning we checked out biological techniques that has a physical check out and acted on The idea of your resources we understood. It took a several years before we started out Performing extra on the big biological troubles. I then began to connect with it nanobiology, a term that did not exist at time.
Nanopores represent an elegant and flexible Device to measure single molecules. We analysis novel detection modes with reliable-condition nanopores and also a variety of strategies to measure proteins with nanopores. Assignments encompass the next:
‘You should not just consider the queries of tomorrow, but in addition look at the inquiries with the working day soon after tomorrow’
Right now, we also recognized that it should be achievable to utilize just one semiconducting carbon nanotube to produce a transistor — and we set out to make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and applied the fundamental silicon substrate for a gate electrode, developing The fundamental three-terminal structure of the discipline-result transistor (Fig.
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial https://www.ceesdekker.net mobile division
1999, initial measurement on the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence to get a new Luttinger description of interacting electrons in nanotubes
2005, discovery of the system of DNA uncoiling by topoisomerase enzymes; discovery of extended-variety conformational variations in Mre11/DNA fix complexes; and to start with power measurements over a DNA molecule in a nanopore
It absolutely was an extremely appealing time, throughout which I acquired loads of assistance from Delft University of Know-how, where I was a professor at enough time, And that i begun a number of collaborations with molecular biologists. That assisted me study a lot.’